The effect of aspartame administration on oncogene and suppressor gene expressions.
Gombos K, Varjas T, Orsos Z, Polyak E, Peredi J, Varga Z, Nowrasteh G,
Tettinger A, Mucsi G, Ember I.
Faculty of Medicine, Institute of Public Health University of Pecs, Pecs, Hungary. firstname.lastname@example.orgBACKGROUND: Aspartame (L-phenylalanineN-L-alpha-aspartyl-1-methyl ester) is an artificial sweetener with widespread applications. Previously published results have shown that among rats receiving aspartame a significant increase of lymphoreticular neoplasms, brain tumours and transitional cell tumors occurred. The aim of our short-term experiment was to investigate the biological effect of aspartame consumption by determining the expressions of key oncogenes and a tumour suppressor gene.
MATERIALS AND METHODS: After one week per os administration of various doses of aspartame to CBA/CA female mice, p53, c-myc, Ha-ras gene expression alterations were determined in individual organs.
RESULTS: The results showed an increase in gene expressions concerning all the investigated genes especially in organs with a high proliferation rate:
Aspartame has a biological effect even at the recommended daily maximum dose.
In Vivo. 2007 Jan-Feb;21(1):89-92.
PMID: 17354619 [PubMed - indexed for MEDLI