BIO Mary Nash Stoddard on Twitter

PRESENTING: MARY NASH STODDARD - Co-Founder of the massive international anti-aspartame movement in the mid 1980's, following the brain tumor death of her forty two year old husband, Mike. Ms. Stoddard suffered a life threatening aspartame-related blood disorder in 1985, whereupon, The NutraSweet Co. offered her an all-expense paid vacation for two anywhere in the world, if she would agree to be tested by their doctors. She declined, with the blessing of her doctor, and the rest is history. She has conducted multi-national lecture tours and is a popular visiting professor at colleges, universities and medical schools. "Deadly Deception - Story of Aspartame" is a toxicology sourcebook, edited by Ms. Stoddard, documenting the harmful effects of the world's most toxic artificial sweetener. The companion one hour "Deadly Deception" video is further documentation - taped at a prestigious scientific conference. Stoddard's efforts, over more than two decades, led to the present rejection of the sweetener by many of the food and beverage giants of industry, as they rush to distance themselves from the liabilities associated with use of a neuro-toxic substance in their products. She has testified in court as an Expert Medical Witness and like her counterpart, Erin Brokovitch, helped with a number of lawsuits on behalf of consumers. Her powerful message has reached millions around the world through the airwaves on radio and television, in print and through popular personal appearances. Honors, Awards, Societies: • Expert Medical Witness [1992-present] * Guest Presenter Gulf War Veterans Annual Conference - [Las Vegas 1999] * Visiting Professor: U. T. Southwestern Medical School [1997] * Visiting Professor: American University School of Journalism [1999] * Visiting Professor: University of North Texas at Denton Dept. of Science [1990 and 2005] • Visiting Professor: University of Houston Bioneers Conference [2006] * Invited speaker: Hebrew Univ. Jerusalem - [1997] * Keynote speech: Mexican Government's Annual Conference on Sweeteners [1999] * Appointed Judge - State of Texas [1977-1984] * Broadcast Journalist - [1965-present] * President's Council on Food Safety - [1998-1999] * International Lecture Tours - [1996-present] * Testimony Senate Committee Hearing on Safety of Aspartame - Washington [1987] * Panelist at National News Conference Announcing Dr. John Olney's Brain Tumor/Aspartame Connection - Washington D.C. [1998] * Inducted Member Texas Radio Hall of Fame [2002-present] Representative of the Texas Rice Growers Association [Miss Rice] Board member: Irving Symphony Orchestra Board Member: Irving Community Theater Founding Board Member Radio Station KNON [public radio], Dallas Charter member City of Dallas Citizens Safety Committee Board Member Dallas Mayor’s Fee Task Force Vice President Operation Get Involved, [liaison committee of the D.P.D.] Board member Dallas Homeowners League President Save Open Space Texas Steering Committee Presidential Election Award for Public Service - Mexican Government State of Texas Board of Adjustment

Saturday, October 30, 2010

NEWS ALERT! Neotame in Beef and Dairy Products - Stoddard's POV - http://marystod.blogspot.com/


Friday, October 29, 2010

ASPARTAME/NEOTAME/SWEETOS ALERT! BEEF SUPPLY IN JEOPARDY!

ONE MORE REASON TO GO VEGETARIAN:

Presently, molasses is used as a feed sweetener to mask the low palatable taste of certain non-conventional feed ingredients. But, the prices of molasses have sky rocketed due to its use as a raw material in alcohol production and other chemical manufacturing industries. Besides, there are stringent regulatory measures for purchase and use of molasses.
"Sweetos is an economical substitute for molasses. Sweetos guarantees the masking of unpleasant tastes and odour and improves the palatability of feed. This product will be economical for farmers and manufacturers of cattle feed. It can also be used in mineral mixture," said Craig Petray, CEO, The NutraSweet Company.

Sweetos is 20 per cent cheaper than molasses, which costs Rs 14 per kg. While Sweetos is priced at Rs 11 per kg, which is available in both powder and liquid form. Ensigns' has a manufacturing facility at Wagholi, where the company manufactures low calorie sweeteners for the food and beverage (F&B) industry containing sucralose. "We are in talks with the animal husbandry department to reach out to farmers and are trying to tie up with extension services with co-operative societies as well. Cattle consume more fodder when mixed with Sweetos. This product has great export potential as well," said Mohan Nair, chairman, Ensigns Helath Care.

The NutraSweet Company is looking at launching the same product in Brazil soon. It will also launch table-top sweeteners and products in India. India also has approved the usage of neotame in the F&B industry in July 2010. Ensigns, therefore, also plans to replace its sucralose based sweetening products with neotame soon.

Aspartame Video Featuring Founder of Aspartame Awareness Movement

The Eclectic Viewpoint

presents

Big Business
Government Coverup Exposed!
Is Your Life In Jeopardy?

Mary Nash Stoddard, March 21, 1992

This is lecture event #3 in Dallas
Grand Mal Seizures
Chronic Fatigue Syndrome
Cancer and Brain Tumors
Depression and Suicide
Infertility
Alzheimer's Disease


All of the above health conditions have increased in alarming numbers and can be caused, in many cases, by food additives or chemicals in our environment, according to this Dallasite who is internationally famous for her individual campaign to educate the public of these dangers.

Mary Nash StoddardMary Nash Stoddard, head of the Dallas based Aspartame Consumer Safety Network (ASCN), was part of a 1987 Senate hearing regarding the safety of aspartame (NutraSweet). Having suffered a near fatal condition (Eosinophilia Myalgia Syndrome) that was later linked, by her doctor, to aspartame, Mary was called to give testimony.

One of the other individuals testifying at the Senate hearing was Air Force Major Michael Collins, an ace F-16 pilot who had felt obligated to reject offers to fly with the famous Thunderbirds because he was having bizarre symptoms of dizziness and tremors — symptoms he was afraid to disclose to anyone for fear of losing his flying credentials. Then in 1985 he had a grand mal seizure and his career as a pilot was over. By chance, his father saw an article linking NutraSweet with seizures and Major Collins was able to identify the source of his problem, but not in time to save his medical certification to fly.

According to General Aviation News, "pilot George E. Leighton experienced blurred vision so severe he was unable to read instruments on his panels and narrowly avoided a tragic landing after consuming two cups of NutraSweetened hot chocolate prior to his flight."

Another pilot writes "I used NutraSweet regularly until I read your story. I was a 48 year old pilot for a local airline until August 1987, when I had a seizure while in flight at the controls of a Piper T 1040 on a charter flight with only one pilot and two non-pilot passengers."

These are just a few of the cases that Mary Stoddard hears daily on the International Pilots Hotline (214-387-4001) in her Dallas office. She says, "We have discussed this issue with the Chief of Aviation Medicine and FAA has no position, officially, since the product is FDA approved. Unofficially, however, he acknowledged increasing reports of various reactions and will not use it himself."

Eighty-five percent of all complaints to the FDA are about aspartame and they fail to act! Part of the problem is that aspartame is classified as a food and not a drug. Two former FDA scientists involved in the original investigations of Searle Pharmaceutical's aspartame say there has been "a giant cover-up and falsification of data." Quoting General Aviation News:"Animals being tested developed brain tumors ... or died. In 1971, an independent researcher found that aspartic acid caused holes in the brains of mice he was testing; more tests by a Searle scientist confirmed the results. Similarly, of seven rhesus monkeys that were fed aspartame, five were afflicted with grand mal seizures. A sixth one died."

In addition to containing aspartic acid, NutraSweet is 50 percent phenylalinine (which can be neurotoxic) and 10 percent methanol (wood alcohol — of which two teaspoons is considered a lethal dose for adult humans). Methanol further breaks down into formaldehyde (embalming fluid), especially if heated in hot beverages.

Mary Nash Stoddard is one of two people in the world recognized as an expert witness to testify in a court of law on the subject of aspartame and has just completed work on a bookThe Deadly Deception. As a dynamic talk show guest, she appeared on London's Thames TV as well as network newscasts and top rated talk shows across America. Her message linking aspartame as the unidentified environmental trigger in many cases of Grand Mal Seizure, Chronic Fatigue Syndrome, Depression, Lyme Disease, Post Polio Syndrome, Alzheimer's, Brain Tumor, Breast Cancer, Multiple Sclerosis and many other mysterious illnesses is one you can't afford to miss! Your life may depend on it! 

Thursday, October 28, 2010

FDA Records Contain Aspartame Death Reports

"We have uncovered serious deficiencies in Searle’s integrity…”
“The cumulative findings of problems within and across the (Aspartame) studies we investigated reveal a pattern of conduct which compromises the scientific integrity of the studies.” --  FDA Task Force 1977

Interview Published in NUTRITION and HEALING

[Cover story Interview with Mary Nash Stoddard, founder of the Aspartame Consumer Safety Network and author of a source book about the sweetener, aspartame.
Dr. Jonathan V. Wright's NUTRITION & HEALING with Alan R. Gaby, M.D., November 1995 - Vol. 2, Issue 11. Pub. by Nutrition & Healing, Inc., Phoenix, AZ.]
Q: Your important consumer education work on the sweetener “aspartame” is well known and we are delighted to speak to you. Is it true that the large majority of non-drug complaints to the Food and Drug Administration are about adverse reactions to aspartame, also called NutraSweet or Equal?
A: Currently, it’s about 78% of all complaints. At one time, the figure was 85%! Yet, this isn’t reported in the newspapers or announced through other media. It’s a well-hidden secret.
Q: Imagine if it were a vitamin or herbal product, we’d have the federal pill police swarming like angry bees. Would you please list for us some of the symptoms caused by aspartame?
A: Aspartame not only causes individual symptoms, it can mimic entire syndromes! For example, the CFIDS (chronic fatigue and immune deficiency syndrome) newsletter calls it the “sweet poison, NutraSweet,” because it can mimic the symptoms of CFIDS. It can also cause grand mal seizures. According to H.J. Roberts, M.D., it can cause decreased vision, pain in the eyes, decreased tears, ringing in the ears, hearing impairment, headache, dizziness and unsteadiness, confusion, memory loss, drowsiness, sleepiness, slurring of speech, numbness and tingling, tremors, depression, irritability, aggression, anxiety, insomnia, phobias, heart palpitations, shortness of breath, high blood pressure, nausea, diarrhea, abdominal pain, itching, hives, menstrual changes, weight gain, hair thinning and hair loss, urinary burning and frequency, excessive thirst, fluid retention, bloating, increased infection, and even death.
Q: Death?
A: Five deaths reported prior to 1987. We don’t know the number since then.
Q: What’s in this stuff?
A: Among other things, it’s about 10% methanol (wood alcohol,) famous for causing blindness in alcoholics. In the body, methanol metabolizes into formaldehyde, a neurotoxin; formic acid, a venom in ant stings; and diketopiperazine, which causes brain tumors in animals. It’s so bad that in July of 1983, the National Soft Drink Association presented official objections to putting aspartame in beverages. I’ll read you one of their objections: “It is well established under Section 402(a)(3) that a food which contains a decomposed substance…is subject to seizure by FDA.” It’s thoroughly established that after a number of weeks and at temperatures over 85 degrees F, there’s no aspartame left in a soft drink, only breakdown products. So, why isn’t FDA seizing it under Section 402 (a)(3)?
Q: Your book, Deadly Deception reports that initially FDA had started investigations of the G.D. Searle Company, makers of aspartame.
A: Yes. In 1977 an FDA task force submitted a 15,000 page document covering their investigation. Here are two quotes:
“We have uncovered serious deficiencies in Searle’s integrity…”
“The cumulative findings of problems within and across the studies we investigated reveal a pattern of conduct which compromises the scientific integrity of the studies.”
Q: These are from FDA’s own task force report on Searle’s aspartame research?
A: Exactly. Your readers may not know that aspartame was originally approved in 1974, but when the brain-tumor issue arose, the approval was withdrawn.
Q: Tell us about the “brain-tumor issue.”
A: Many of the test animals fed aspartame developed large tumors. These were actually cut out, and the animals returned to the study. In some cases, the tumors weren’t even examined for malignancy, and the tumors weren’t reported to FDA. In several cases, animals were reported as dead and later reported as alive again.
Q: No wonder FDA’s task force “uncovered serious deficiencies in Searle’s integrity!”
A: The results of the task force investigation of aspartame and other Searle drugs were presented to the U.S. Senate Subcommittee on Labor and Public Welfare. Senator Edward Kennedy said that “the extensive nature of the almost unbelievable range of abuses discovered by the FDA on several major Searle products is profoundly disturbing.”
Q: So, how did aspartame ever get approved and progress so far into our food supply?
A: Well, for one thing, a former member of Congress and Chief of Staff in the Ford Administration, Donald Rumsfeld, was hired as President of Searle in 1977. Rumsfeld was paid $2 million in salary and $1.5 million in bonuses between 1979 and 1984.
Q: Oh-oh.
A: Also, in 1977, Senior Assistant U.S. Attorney, William Conlon was assigned to the Searle case. He took no action, despite repeated prodding by Richard Merrill, Chief Counsel to the FDA. One year later, Conlon took a position with Sidley and Austin, the law firm representing Searle.
Q: A pattern seems to be emerging.
A: Rumsfeld, now Searle president, hired: John Robson as Executive Vice-President – he had been a spokesman of the Civil Aeronautics Board; William Greener as Chief Spokesman for Searle – he had been a spokesman in the Ford White House; and, Robert Shapiro as General Counsel, who later became head of Searle’s NutraSweet Division – he had been a Special Assistant in the Department of Transportation. But, here’s the pay-off!
Q: No pun intended?
A: The facts are interesting, aren’t they? In 1983, the Commissioner of the FDA, Dr. Arthur Hull Hayes, Jr. approved NutraSweet for soft drinks two months before leaving office. Two-to-three months later, he accepted a position as Senior Medical Advisor to Searle’s public relations firm, Burson Marsteller. He was paid $1,000 per day as consultant.
Q: Really, $1,000 a day? This is a matter of public record?
A: A matter of public record. And, Michael Taylor was also involved in the approval of aspartame.
Q: Michael Taylor, the Bovine Growth Hormone (rBGH) man, who worked for FDA, lawyered for Monsanto to get rBGH approved, then went to work for FDA writing their BGH regulations?
A: The very same. Didn’t you know that G. D. Searle is a wholly-owned subsidiary of Monsanto, with Robert Shapiro as current CEO?
Q: What a surprise. And a not unfamiliar pattern. But, tell us about aviation and aspartame.
A: The official Air Force safety magazine, FLYING SAFETY, and the Navy’s flight magazine, NAVY PHYSIOLOGY, have both published warnings about using aspartame and flying.
Q: Will you give us an example?
A: A pilot called ACSN’s Pilot Hotline two nights ago and told me about his experience. Flying for Peninsula Airlines in Alaska, he had a seizure in flight at 10,000 feet and was grounded. He had been drinking eight to ten cups of coffee a day sweetened with Equal, another aspartame compound. Since he quit aspartame, he’s been seizure-free, but he hasn’t been allowed to fly.
Q: We need to know more about this.
A: In my book, Deadly Deception, there’s a reprint of a scientific paper showing that aspartame aggravates abnormal brain waves in children with epilepsy (Neurology 1992;42:1000-1003.)
Q: Maybe airline passengers should question pilots about aspartame use before boarding! What about those U.S. Senate hearings during which pilots testified about the adverse effects of aspartame on their flying abilities?
A: There have actually been three hearings.
Q: Here we go again!
A: Speaking of contributions… watch out diabetics! The NutraSweet company has given money, money, money to the American Diabetic Association. And, remember when you hear a registered dietitian say aspartame is safe for pregnant women, children, and everyone else, the Registered Dietitian’s professional association has been given $75,000 to expound on the virtues of aspartame. The American Dietetic Association has even stated that the NutraSweet company writes their “Fact Sheets.”
Q: So, there’s money everywhere…to members of Congress, former regulatory bureaucrats, professional associations…
A: Absolutely. Aspartame approval and persistence on the market has everything to do with money and politics, and almost nothing to do with science and reason. Even the FDA’s own reviewers were against aspartame until those political/financial events I’ve mentioned.
Q: Is there any hope to reverse all this?
A: Each of us will have to do it ourselves, one at a time and by spreading the word. Fortunately, it appears that the public pays more attention to this issue when they’re given access to the information I’ve been outlining. The last TV show I appeared on about this issue, received 100,000 calls over the next three days.
Q: Thank you so much for devoting your time and energy to spreading the word about the hazards of aspartame.
A: Your readers can email the ASPARTAME CONSUMER SAFETY NETWORK (aspartamesafety.com) at marystod@airmail.net for more information as well as many suggestions for helping to make known the truth about aspartame.
*(U.S. Attorney, Samuel Skinner was prosecuting G.D. Searle for falsifying tests submitted for approval of aspartame, but recused himself at the last minute to join Searle’s law firm, Sidley and Austin. Skinner then went back into Government, becoming head of the Dept. of Transportation – over the FAA. From there he was appointed Chief of Staff in President Bush’s White House. Recently, he was nominated Man-of-the-Year by the Epilepsy Foundation in Chicago. Ironically, aspartame is reported to “trigger” epilepsy in a number of Epileptics. Also, former Monsanto Attorney, Clarence Thomas was appointed Supreme Court Judge amidst swirling controversy over his appointment! Ed.)

Tuesday, October 26, 2010

YOUR BRAIN ON ASPARTAME - A MUST-READ




Mike Adams Interview with Neurosurgeon/Author Dr. Russell Blaylock

Mike
: I'm here with Dr. Russell Blaylock, and I'd like to explore some of the more advanced aspects of some of the things you are working on. Dr. Blaylock, I think readers know the basics of both MSG and aspartame, but can you review what you've already written about excitotoxins?
Dr. Russell Blaylock: I have three books. The first one is the excitotoxin book, "Excitotoxins: The Taste That Kills," and the latest one is "Health and Nutrition Secrets That Can Save Your Life." The third one is "Natural Strategies for Cancer Patients," which is directed at nutritional treatments for cancer. It contains some material about aspartame and MSG.
Excitotoxins have been found to dramatically promote cancer growth and metastasis. In fact, one aspartame researcher noticed that, whencancer cells were exposed to aspartame, they became more mobile, and you see the same effect with MSG. It also causes a cancer cell to become more mobile, and that enhances metastasis, or spread. These MSG-exposed cancer cells developed all of these pseudopodians and started moving through tissues, which is one of the earlier observations from cancer.
When you increase the glutamate level, cancer just grows like wildfire, and then when you block glutamate, it dramatically slows the growth of the cancer. Researchers have done some experiments in which they looked at using glutamate blockers in combination with conventional drugs, like chemotherapy, and it worked very well. It significantly enhanced the effectiveness of these cancer drugs.
Mike: Wasn't there some research that came out recently that supports all this by establishing a correlation between leukemia and aspartame?
Dr. Blaylock: Yes. This Italian study was very well done. It was a lifetime study, which is very important with these toxins. They fed animals aspartame throughout their lives and let them die a natural death. They found a dramatic and statistically significant increase in the related cancers of lymphoma and leukemia, along with several histological types of lymphomas, which is of interest because H.J. Roberts had written an article saying that there was a significant increase in the primary lymphoma of the brain.
When you look it up in the neurosurgical literature, there is a rather significant rise in the incidents of what used to be a rare tumor. We're seeing a lot more of the primary lymphoma of the brain, which is a little different than lymphomas you see elsewhere. When you look back at the original studies done by the G.D. Searle company, they found lymphomas as well as primary brain tumors and tumors of multiple organs. All of this correlation shows that we've got a powerful carcinogenic substance here. It is either acting as a co-carcinogen or a primary carcinogen. Most likely, it's the formaldehyde breakdown product.
What the Italian study found is that if you take these same animals and expose them to formaldehyde in the same doses, they developed the same leukemias and lymphomas. If you look back at the Troker Study conducted in Spain a couple of years ago, what they found was when they radiolabeled the aspartame, they could actually see formaldehyde binding to the DNA, and it produced both single and double strand DNA breakage.
We know that when formaldehyde binds to DNA, it's very difficult to remove it. It will stay there for long periods of time. What that means is if you just drink a single diet cola today, or sweeten something with NutraSweet, you're accumulating damage every day. Eventually, you're going to produce this necessary pattern of DNA damage to initiate the cancer, and once you develop the cancer, the aspartic acid component of aspartame will make the cancer grow very rapidly. You've got a double effect; it's causing the cancer, and it's making the cancer move very rapidly.
Mike: Given all this evidence, how has the industry managed to suppress this information and keep this chemical legal in the food supply?
Dr. Blaylock: Donald Rumsfeld was the one who pushed a lot of this through, when he was in the chairmanship of the G.D. Searle company, NutraSweet. He got it approved through the regulatory process, but once it was approved, the government didn't want to admit that they had made a mistake. They just continued to cover it up, like the fluoride thing and the milk industry.
You're not going to criticize milk in the media, because they are smart enough to advertise innewspapers, magazines, health magazines and journals. They have all the media outlets covered. The only place that they don't have covered is talk radio and the internet. The health blogs can tell the truth.
No matter how much a newspaper wants to tell the truth, they're not going to do it. This is the kind of pressure these people are under. Even if you have a good writer who wants to write the story, his editor is going to override him and prevent it or water it down considerably. You see this in journals like the Journal of Clinical Nutrition or College Nutrition. Look at who funds them: The Monsanto Company, and they used to be sponsored by G.D. Searle. They're not going to want to put articles in their journal that will infuriate their primary source of income. Even medical and nutrition journals are controlled by these people.
Mike: It's the unholy alliance between the scientific community and big business.
Dr. Blaylock: Right. Another big scandal concerning the research is something new we found. We discovered that outside of the brain, there are numerous glutamate receptors in all organs and tissues. The entire GI tract, from the esophagus to the colon, has numerous glutamate receptors. The entire electrical conducting system of a heart is replete with all sorts of glutamate receptors. The lungs, the ovaries, all the reproductive systems and sperm itself, adrenal glands, bones and even calcification are all controlled by glutamate receptors. They act and operate exactly like the glutamate receptors in the brain.
So, when you're consuming MSG, the level of glutamate in the blood can rise as high as 20-fold. You get very high glutamate levels in the blood after eating a meal containing MSG. You're stimulating all of the glutamate receptors. That's why some people get explosive diarrhea, because it stimulates the receptors in the esophagus and small bowel. Others may develop irritable bowel, or if they have irritable bowel, it makes it a lot worse. If they have reflux, it makes that a lot worse. The thing about the cardiac conduction system glutamate receptors is this may explain the rise in sudden cardiac death.
What you see in almost all these cases is low magnesium. When the magnesium level is low, the glutamate receptors become hypersensitive, and so people -- athletes in particular, if they are not supplementing with magnesium -- are prone to sudden cardiac death, because of the glutamate receptors. If they eat a meal or something that contains glutamate or drink a diet cola before practice, it will produce such intense cardiac irritability, they'll die of sudden cardiac death. We know the sudden cardiac death is due to two things: Most commonly arrhythmia and cardio artery spasm. Both of which can be produced by glutamate.
Mike: Of course, that death certificate doesn't say they died from MSG.
Dr. Blaylock: No, and it's not going to, because the admitting physician doesn't know the first thing about any of this research. They've never heard of it. In fact, most cardiologists I've spoken with have never heard of this. They didn't know there were glutamate receptors throughout the electrical conduction system and in the heart muscle itself. You have a million patients in this country with arrhythmias that are life-threatening, and no one's telling them to avoid MSG and aspartame, yet it's a major source of cardiac irritability.
Mike: It's absolutely astounding. Now, didn't baby food manufacturers voluntarily remove this ingredient in the '70s?
Dr. Blaylock: They said they would, but they didn't. What they did is take out pure MSG and substitute it with hydrolyzed protein and caseinate. If you look at most toddler foods, they all have caseinate hydrolyzed protein broth, a significant source of glutamate.
Mike: We're destroying the nervous systems of these babies.
Dr. Blaylock: Exactly. Now, one of the things we're hearing a lot about is childhood obesity. One early observation with exitotoxicity is it makes animals grossly obese.
Mike: If they banned MSG, the drug companies would lose billions. Think about how much money they make treating all of these symptoms.
Dr. Blaylock: Here the government has all these big plans for controlling carbohydrate intake and controlling cereals and sugar and all that. Those things add to the problem, because what we find in MSG-exposed animals is that they prefer carbohydrates and sugars over protein-rich foods. That was one of the characteristics of this type of obesity. It's very difficult to exercise the weight off and almost impossible to diet it off. The appetite is out of control, but the metabolism is also out of control. They have metabolic syndrome on top of obesity, and so then you have a leptin insensitivity. In terms of obesity, they have a leptin insensitivity. It has been shown that you can produce leptin insensitivity very easily with MSG.
Mike: Is there any hope, in your view, that the world may wake up to this, and some day these ingredients may be banned?
Dr. Blaylock: It's possible, but you know, it's only going to be by public exposure, through the blogs and sites like yours. Once the public gets wind of it and is convinced that this is real, then there'll be an uproar over it. There's just a deception. The average consumer looks at it and goes, "Well, it says that it contains no MSG, so it must be okay."
Mike: I find a lot of the vegetarian foods, or so-called health foods, use yeast extracts.
Dr. Blaylock: The worst of the things they're doing are the soy extracts. Soybeans, naturally, have one of the highest glutamate levels of any of the plant products. When you hydrolyze it, you release the glutamate, and the soy protein isolates. The glutamate levels are higher than a lot of what you'll find in MSG products, yet the vegetarians are just eating it like it's the healthiest thing in the world. There was a 25-year study done, which looked at people who consumed the most soy products, and they followed them for 25 years and did serial CT scans. They found out that the people who consumed the most soybean products had the greatest incidence of dementia and brain atrophy.
These people are destroying their nervous system, and I talked to a lot of them who complained of severe migraine headaches. I said, "Get off the soy," and they do, and that migraine headache goes away. In addition, you have very high manganese levels, which istoxic to the very same part of the brain that produces Parkinson's. You've got a mixture of toxins with soy products, and the people think they are eating a healthy, nutritious product. It's destroying their nervous system, as well as other organs.
Mike: In this whole debate of soy versus cow's milk, we find misinformation in both camps.
Dr. Blaylock: I wouldn't recommend either one. If you're obsessed with milk, use goat's milk. It's closer to human milk, but I wouldn't recommend cow's milk or soy milk. I think people ought to avoid soy products as if they were poison.
Mike: Have you taken a lot of heat from NutraSweet or any of these other companies? I mean, have you been threatened with lawsuits or anything for going public with this information?
Dr. Blaylock: No, they leave me alone. I know too much. They've never bothered me. When I wrote the book, George Schwartz warned me, "Are you sure you want to write this book? If you do, they're just going to hound you to death." I said, "Yes, I want to write the book." So, I wrote it with one thing in mind: that they would not be able to refute it.
I researched every kind of way you can research and proved the toxicity of glutamate. They know I know that, because I had exchanged this in writing letters to some of their biggest defenders. They all realized that they couldn't answer my arguments. So they leave me alone. They're afraid that if it comes to a big standoff between me and them, they're going to lose.
Mike: They don't want this information going on the public record.
Dr. Blaylock: No, they don't want that. What they're doing is the old ploy of just ignoring and hoping it will go away. Of course, they put pressure on magazines, journals and newspapers not to interview me. They are trying to keep me in the shadows where they hope most people don't hear anything I have to say. It only works for so long.
Since I first wrote the book in 1995, proof supporting my viewpoint has increased enormously. The new material on peripheral glutamate receptors absolutely killed these people. They have no defense against that. The new information on the dramatic increase in cancer aggressiveness is something that they are terrified of.
Mike: Now you find these receptors outside the brain.
Dr. Blaylock: Right. Now, see, I proved it can enter the brain and that all that was a lie. What they've shown is that there are glutamate receptors on both sides of the blood brain barrier and that when you expose these receptors to glutamate, it opens up the blood brain barrier. So, the glutamate itself can open the barrier, and I list all these conditions. For instance, as you get older, your barrier becomes less competent. Almost all Alzheimer'spatients have incompetent barriers. Heat stroke, seizures, autoimmune disorder and multiple sclerosis all are related with this active blood brain barrier.
You're talking about tens of millions of people, and they are out there gobbling up aspartame, MSG and other excitotoxins, and no one is telling them they are making their neurological conditions infinitely worse. I don't know how many seizure patients I've gotten off their medicines by just getting them off MSG and giving them magnesium. They quit having seizures. They were on maximum dosages of medications and still having seizures. Most neurologists and neurosurgeons that treat seizures are not aware of this.
Mike: It's not profitable to teach people how to avoid these ingredients.
Dr. Blaylock: If you look at the neuroscience literature, you can't pick up an article that's not about excitotoxicity. The hottest topic in neurosciences is glutamate receptors and excitotoxins.
Mike: Are they talking about it in the food or just as a chemical?
Dr. Blaylock: They won't mention food, but they talk about the glutamate receptor and what happens when you activate it.
Mike: What about the argument from food companies? I actually got into a debate with a veggie burger manufacturer, because I wrote an article that said their product had yeast extract in it, and yet the front label said, "100 percent all-natural ingredients." They said, "Well, glutamate appears naturally in other foods, like tomatoes and seaweed." What's your answer to that kind of defense?
Dr. Blaylock: Sure, but you see, all of these types of glutamate are bound. They're in oligosaccharides, polysaccharides. They are bound in amino acids groupings. They're not free amino acids. If you have it as a complex protein, you absorb it in your GI tract. In the GI tract, there are almost no free amino acids if you eat foods such as tomatoes. The level of free amino acids is nil; it's almost all absorbed as combined amino acids, and then it's only broken down in the liver, where it's released in very low concentrations that the body can deal with. It was never meant to have free amino acids in such high concentrations.
Well, when you hydrolyze them -- or you use yeast extract or enzymes to break down these various proteins into their free, released amino acids -- they're not natural any longer. What you've done is artificially release the amino acids in an unnatural way, and when they enter your GI tract, they are absorbed as free amino acids, then your blood level of that glutamic acid goes up significantly. As I said, it can go up as high as 20-fold, in some cases 40-fold. Your blood brain barrier is not constructed to handle such high levels of glutamate, because it doesn't naturally occur that way. It can handle the lower levels, but it can't handle these very high levels. So this argument, "Oh, it's natural," is just a lot of nonsense.
Mike: I do find that many manufacturers claim to be natural health companies, or health foodcompanies, as a cover. They don't really follow that philosophy, because they'll use these ingredients.
Dr. Blaylock: Sure, and they use all kinds of backhanded ways.
Mike: Here's a practical question that's actually been burning in my head for about eight years: Is there anything that a person can take to block the absorption of MSG or glutamate as a defensive supplement?
Dr. Blaylock: Well, not necessarily to block it. You have other amino acids that can't compete for glutamic acid absorption. So that may be one way to help reduce the rate at which it would be absorbed.
Mike: Which aminos would those be?
Dr. Blaylock: Those would include leucine, isoleucine and lysine. They would compete for the same carrier system, so that would slow down absorption. There are a lot of things that act as glutamate blockers. You know, like silimarin, curcumin and ginkgo biloba. These things are known to directly block glutamate receptors and reduce excitotoxicity. Curcumin is very potent. Most of your flavonoids.
Magnesium is particularly important, because magnesium can block the MNDA glutamate type receptor. That's its natural function, so it significantly reduces toxicity. Vitamin E succinate is powerful at inhibiting excitotoxicity, as are all of your antioxidants. They found combinations of B vitamins also block excitotoxicity.
Mike: Let's talk about restaurants. I can't even eat at restaurants anymore at all, even those natural restaurants. They don't know they have MSG, because it's in one of the sauces or something.
Dr. Blaylock: I talked to them, and they said, "We get our food in these big crates, so there's no ingredients listed." It's the same thing for hospitals. I talked to a hospital dietitian and she said, "We can't tell because it comes in a crate, and they won't put the ingredients on it. It just says Salisbury steak or whatever."
They don't know, so it's hard for them to come out and tell their customers, "It's free of MSG." What they mean when they do say that is, "We didn't put any in there." Their white sauces are particularly high, as are their salad dressings, especially the ones that are pure oil. They all contain MSG.
Mike: Gravy mixes almost always have it, right?
Dr. Blaylock: Yes, they'll put hydrolyzed protein in it. They're selling taste. I mean, that's why a person prefers one restaurant to another. The food tastes better. Then they go home and feel sick and don't understand why.
One of the things that has been noticed about sudden cardiac death is that most that have it, other than athletes, die after eating a meal in a restaurant. I suspect it's because these people have low magnesium. They eat the meal, the glutamate stimulates the glutamate receptor in the cardiac conduction system as well as the hypothalamus, and they have a sudden cardiac death.
I was in a bookstore in Oxford, Miss. This young guy was there, and he just dropped and died. We took him to the hospital and tried to resuscitate him, and we couldn't. He was only 26 years old, and he had just eaten a big bowl of soup at one of the restaurants. Well, I talked to the person that was there, and he said they use a lot of hydrolyzed protein and MSG. People will eat a meal, have a soup before the meal, get this huge dose of MSG, and drop dead from the arrhythmia.
Mike: Could this explain some sudden infant deaths as well, you think?
Dr. Blaylock: Oh yeah. I mean, look at the popularity of these soy infant formulas. Mothers are crazy to give their kids soy formula. There is a lot of concern about it. There's concern about the fluoride level, the manganese level, and the glutamate levels in these soy infant formulas.
Mike: At Wal-Mart, I saw bottled water with added sodium fluoride. It's fluoride water.
Dr. Blaylock: Oh yes, it's for babies. They have a picture of a baby on it.
Mike: So, is there a website or a newsletter that people can visit or sign-up for?
Dr. Blaylock: I have a newsletter. It's www.BlaylockReport.com. It's by subscription, but you can buy individual newsletters. You don't have to get the whole year. It's issued monthly, for $3.98 a piece. It covers everything.
I try to cover a lot of common subjects and bring people up to date on the new thinking and research. I go through all the medical research. Usually I'll go through everything that conventional medicine has to offer. A lot of times they have good physiology, a good pathophysiology, but then, they switch over and start talking about drugs. I'll go through all the good pathophysiology material they have, and then I'll look up all the nutritional research that's been done that can correct those problems.
Mike: I see. Here's an off-the-wall question: If MSG and all its different versions, as well as aspartame, were outlawed tomorrow, what changes would we see in the next five years in terms of public health?
Dr. Blaylock: I think you'd see a significant drop in obesity and metabolic syndrome. You'd see a tremendous drop in certain cancers. You would certainly see a tremendous drop in the neurodegenerative diseases, and all of these diseases that are increasing expeditiously.
The neurodegenerative diseases are just exploding. Things that used to be rare, we're seeing all the time now. It's just frightening. And when you look through the neurosciences literature, they have no explanation. They don't know why it's increasing so rapidly, but it's because we have such a large combination of toxins. For instance, we know that cellular neurodegenerative diseases are connected to mercury, aluminum, pesticides and herbicides, and the way they produce brain damage is through an excitotoxic mechanism.
So, we are all exposed to those toxins, and then when you add MSG and excitotoxins to the food, you tremendously accelerate this toxicity. That's why we're seeing this explosion in neurodegenerative diseases; Alzheimer's and autism and ADD and Parkinson's -- all these things are increasing so enormously because we are exposed to carcinogenic toxicity from all these different things and this huge exposure to excitotoxins, which is the central mechanism.
This is what no one's been able to claim. You look at one person's report and they'll say, "Alzheimer's is related to mercury exposure," and then another one says, "No, it's related to pesticides," and yet another one says it something else, but they're all operating through the same mechanism. All of these things operate by increasing brain immune activity, and that activates excitotoxicity. So that's why all of them seem to be related, because they're all doing the same thing to the brain.
Mike: What about the American Diabetes Association? Given that aspartame actually promotes obesity, based a lot of the work you've uncovered, I find it curious that the ADA so strongly supports aspartame.
Dr. Blaylock: I don't, considering they receive huge amounts of money from the makers of aspartame. They fund their walk-a-thon and all that kind of stuff, so they get tremendous amounts of money from the makers of aspartame, and money talks.
Whether they're just deluding themselves and choosing not to believe it's toxic, refusing to look at the evidence, or they're just concerned about the money and could care less, I don't know, but when you look at the pathophysiology of diabetes and the effect of aspartame, it's absolute nonsense for anybody who has diabetes to be on aspartame. Particularly in a neurological aspect, it's going to make it a lot worse.
Mike: What about other popular chemical sweeteners like sucralose in Splenda?
Dr. Blaylock: There's really not a lot of research in those areas. They have some basic research, like with Splenda, showing thalamus suppression. If that holds up in other research, it's a major concern. If you're suppressing the thalamus gland in a child, that's the future of their immune function. You can increase everything from autoimmunity to producing immune-related diseases, to infections and cancers. The implications of thalamus gland suppression are enormous.
There have been reports of miscarriages associated with Splenda in experimental animals. The problem is, we don't have a lot of well-conducted studies on Splenda to ferret these things out, and they're not going to do them. The best way to protect your product is to never test it, or just to set up some phony test and report it in a journal that's friendly to your point of view.
That's what they did with certain vaccines. They did thousands of phony studies and waved them around, claiming nothing was found. You can design any study to find whatever you want. Particularly, you can design it to have negative results. That's the easiest thing to do.
Mike: We've got government health officials telling us mercury is safe and we've got big business telling us both aspartame and MSG are safe. It sounds like every poison in the food supply or in organized medicine is perfectly safe.
Dr. Blaylock: We did that with lead. When they first started questioning the safety of lead, the levels they said were safe were just enormously high, and then a mere 10 years later, suddenly we're finding out that lead is toxic at 10 micrograms. In the '60s, they were fighting over the same thing. The defenders of gasoline-added lead were saying lead wasn't toxic, except in extremely high doses. Then neuroscience literature was contradicting them, but nobody would listen. Finally, the weight of the evidence was so overwhelming that they found out extremely low concentrations of lead were toxic and accumulate in the brain.
It's the same thing with mercury. Mercury is even more poisonous than lead. An infant is getting 150 times the dose of mercury than the EPA safety limits. A hundred times higher than the FDA safety limits. Here's a little baby that's getting 150 times higher a dose than the FDA says is safe for an adult.
Mike: What are the big points readers to take away? What do you think they need to remember in order to protect themselves?
Dr. Blaylock: You need to abstain from all of these things. Aspartame is not a necessary nutrient, and neither is MSG. The weight of the evidence is overwhelming. If you want to avoid obesity, metabolic syndrome and cancer, and if you don't want to make your cancer more aggressive, then you need to stay away from these products.
The damage affects pregnant women, unborn babies and newborns. It produces changes in the brain that are irreversible. What we've found is that it reprograms the wiring of the brain, particularly the hypothalamus, so it doesn't function normally. These children are abnormal for the rest of their lives in terms of their physiological function.
Mike: Well, hopefully the weight of this evidence will someday become overwhelming, and government regulators will listen to you.
Dr. Blaylock: The pressure on researchers is so enormous. Larry Troker came out with his research about the DNA damage by aspartame. Then his career was damaged by the makers of aspartame. He said he would never do another research project concerning aspartame. Well, a number of researchers have said the same thing. Once they published their results, the full weight of these companies come down on their head. NutraSweet will contribute millions to a university and threaten to pull their donations if someone isn't quieted.
Mike: So there's blatant scientific censorship at work here.
Dr. Blaylock: There's blatant, and then there's just understood. You have NutraSweet manufacturers donating several million dollars to your university. The director of that laboratory, or the president of the university, will just quietly let them know that they'd really like to see research come to a stop.
The editor-in-chief of The Chemical News went through that with fluoride. They fired him because he refused to be quiet about fluoride toxicity, and they had just received this huge grant from Colgate-Palmolive. They said, "We'll lose our grant if you don't get quiet about fluoride." He wouldn't, and they fired him. Researchers know this.
Mike: I want to commend you for being willing to stand up and tell the truth about all of this. I think you're doing a great, positive service to public-health.
Dr. Blaylock: You're the one doing the service, because you're putting the word out there. Without you, I would just be sitting in a room fussing. It's people like you that get this word out and let people know what's going on in the world.
Mike: I wouldn't be surprised if they tried to pass a bill to outlaw health talk on the internet.
Dr. Blaylock: They're trying to do it. You know, they passed a law at one time in several states that no one but dietitians could speak on the subject of nutrition. Several states had that law passed. This meant Ph.D. biochemists couldn't talk about health. It was ridiculous. I'm sure that one day they're going to have an internet bill saying there's just too much dangerous material coming over the internet on health issues, and we need to regulate it.
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Labels: Aspartame, MSG, Alzheimers, MS, FAA, Pilots, FDA Coverup of Food Safety Issue, Aspartame Timeline, Neuroexcitotoxins - Nerve Toxins, Isolated Amino Acids, Glutamic Acid, Aspartic Acid Dangers, Cancers, Seizures, Obesity, Heart Disease, Mental: Agressive/Bizarre Behavior, Mood Swings, Serotonin Blocker, Deaths

Monday, October 25, 2010

Sunday, October 24, 2010

Aspartame Causes Weight GAIN and Cancers [studies prove]

By Sheryl Ubelacker
 

 TORONTO (CP) - For those who drink diet pops in the belief that sugar-free beverages are healthier than regular soft drinks, new research suggests they should think again.

A huge U.S. study of middle-aged adults has found that drinking more than one soft drink a day - even a sugar-free diet brand - may be associated with an elevated risk for metabolic syndrome, a cluster of factors that boosts the chance of having a heart attack or stroke and developing diabetes.

Officials of a leading aspartame awareness group, Aspartame Consumer Safety Network, reported today to confirm the findings of the Framingham Heart Study

"We found that one or more sodas per day increases your risk of new-onset metabolic syndrome by about 45 per cent, and it did not seem to matter if it was regular or diet," Dr. Ramachandran Vasan, senior investigator for the Framingham Heart Study, said Monday from Boston.

"That for me is striking."

Metabolic syndrome is associated with five specific health indicators: excess abdominal fat; high blood sugar; high triglycerides; low levels of the good cholesterol HDL; and high blood pressure.

"And other than high blood pressure, the other four . . . all were associated with drinking one or more sodas per day," said Vasan, a professor of medicine at Boston University.

Having metabolic syndrome is known to double the risk of heart attack and stroke, as well as boosting the risk of diabetes.

The study included nearly 9,000 observations of middle-aged men and women over four years at three different times. The study looked at how many 355-millilitre cans of cola or other soft drinks a participant consumed each day.

The researchers found that compared to those who drank less than one can per day, subjects who downed one or more soft drinks daily had a:

-31 per cent greater risk of becoming obese (with a body mass index of 30 or more).

-30 per cent increased risk of adding on belly fat.

-25 per cent higher risk of developing high blood triglycerides or high blood sugar.

-32 per cent higher risk of having low HDL levels.

But Vasan and his colleagues, whose study was published Monday in Circulation: Journal of the American Heart Association, are unsure what it is about soft drinks that ratchets up the risk of metabolic syndrome.

"We really don't know," he said. "This soda consumption may be a marker for a particular dietary pattern or lifestyle. Individuals who drink one or more sodas per day tend to be people who have greater caloric intake. They tend to have more of saturated fats and trans fats in their diet, they tend to be more sedentary, they seem to have lower consumption of fibre."

"And we tried to adjust for all of these in our analysis . . . but it's very difficult to completely adjust away lifestyle."

Dr. David Jenkins, director of the Risk Factor Modification Centre at St. Michael's Hospital in Toronto, said previous studies have suggested that diet pops did not have the same effects on weight and health as do naturally sweetened soft drinks.

 "The unusual thing that needs comment is they (the study authors) say that the diet colas are the same as the calorically sweetened colas," said Jenkins. "So I think that is the piece that they've put into this puzzle . . . I think we need a lot more scrutiny of that."

 Jenkins said he believes that high consumption of soft drinks likely goes along with eating a high-calorie diet.

 "I think the disappointing thing is if you thought you were doing (yourself) a major service - which you always used to think - by taking diet drinks, this is not helping you," he said. "Before we were saying take the diet (drink) and you're OK. Now were saying: 'Watch it."'

 The study also begs the question whether there is some ingredient in soft drinks - regular or diet - that may encourage metabolic syndrome.

 But Dr. Arya Sharma, chair of cardiovascular obesity research at McMaster University, said there is nothing suggested by the authors of the study that would lead to that conclusion.

 "One thing that they say and other people have said before is if you drink a lot of sweet things, then you are sort of conditioning yourself for that sweet taste," Sharma said Monday from Hamilton. "So people who drink diet pop may be eating other sweets, whether that comes in the form of dessert or other things, I don't know."

 "It may be that people who are drinking diet pop - and we have this effect often with people who go on diets or when people go running or whatever - that you do a little bit of something that you think is good, and then you overcompensate by doing more of something that is bad."

 "The idea could be because I'm drinking diet pap, I can afford to splurge on dessert."

 Vasan said he cannot out-and-out recommend that people stop drinking soft drinks based on this study, because the findings are based on association, not clear cause and effect.

 "The simple message is eat healthy, exercise regularly and everything should be done in moderation," he said. "If you're a regular soda drinker you should be aware that this study adds to the evidence that regular soda may be associated with metabolic consequences."

 "If you're a diet soda drinker, stay tuned for additional research to confirm or refute these findings."

CDC review 

In Nov. 1984 the CDC compiled a report reviewing 213  of 592 cases of aspartame complaints. Some of these included cardiac arrest,  seizures, disorientation, hyperactivity, extreme numbness, excitability,  memory loss, loss of depth perception, liver impairment, severe mood swings  and even DEATH. Frederick L. Trowbridge added an executive summary that conflicted with the information in the report by stating that the complaints were "generally of a mild nature." Death, of course, not a mild nature symptom!!!

DR. JEROME BRESSLER REPORT TO FDA:
[Test Results from Lab showing Aspartame causes Cancers, precancerous growths/conditions and Death. Kept under FDA seal of secrecy until FOIA forced their release to public. By then, Aspartame had already been approved by political manipulations.]

Original:

    Pituitary  - Markedly enlarged; slightly hyperemic.
    Heart      - Left Ventricle has undergone dilitation walls thin.
    Lung       - Right, anterior, medial and post-caval lobe have
                 undergone consolidation.
    Testes     - Marked atrophy, bilaterally.

    Seminal Vesicle - Marked atrophy, bilaterally.

 Thyroid   - Moderately enlarged, bilaterally.  A 2 mm in dia., dis-
             crete, sl raised, moderately firm yellowish-grey lesion
             is located in the posterior tip, bilaterally. (Thyroid
             submitted in toto wrapped in a lens paper).

 Heart      - Wall of left ventricle thin
   Brain      - Marked autolysis
   Pituitary  - Marked autolysis
 Pituitary        - Marked enlargement.
Pitutiary         - appears markedly hyperemic
 Heart      - Left ventricle has undergone a moderate amount of dili-
                tation.  Wall, left ventricle is thin.

 Female Rat No. F16CF  (Path No. 95619)
           Heart - Focal Fibrosis.
           Kidney - Mild chronic nephritis.

  Female Rat No. K29CF (Path No. 95631)
           Heart   - Focal fibrosis
           Kidney  - Focal calcification

        Female Rat No. M4CF  (Path No. 95632)
           Liver   - Focal hyperplasia
          
        Female Rat No. M10CF  (Path No. 95634)
           Kidney  - Focal calcification.
           Pituitary - Adenoma
           Ovary   - Fibrosis and Pigmentation.

                            (65)

        Female Rat No. M15CF  (Path No. 95635)
            Pituitary   - Adenoma.
            Ovary       - Cyst.

        Female Rat No. B30CF  (Path No. 95801)
            Kidney      - Focal calcification.

        Female Rat D29CF  (Path No. 95803)
            Urinary Bladder (1)  Chronic diffuse inflammation.
                            (2)  Diffuse mild hyperplasia.

 The second phase of the review consisted of the microscopic examination of
 all tissues from the high dose females - a total of 36 animals.  The
 inconsistencies are listed below:
       
        Female Rat No. B14HF  (Path. No. 95657)
          Eye was reported as not examined but eye was present and
          normal. 

        Female Rat No. F25HF (Path. No. 95823)
          Urinary Bladder - Mild diffuse hyperplasia.
       
        Female Rat No. H7HF (Path No. 95623)
          Ovary - Neoplasm - probably granulosa cell tumor.

        Female Rat No. H9HF (Path No. 95665)
          Heart - Focal fibrosis.
          Urinary Bladder - Mild focal hyperplasia.

        Female Rat No. H15HF  (Path No. 95665)
          Lymph Node - The diagnosis of lymphoma, benign, was present on
          the Searle microscopic report.  According to Dr. Frith, lymphoma
          is generally not considered to be benign and he would diagnose
          lympphosarcoma.

        Female Rat NO. H18HF  (Path No. 95667)
          Pituitary - Adenoma.
          Brain - Mild bilateral hydrocephalus.

        Female Rat No. K18HF (Path No. 95824)
          Pituitary - Adenoma

        Female Rat No. K24HF (Path. No. 95671)
          Mass noted grossly - nothing consistent with mass reported
         microscopically.

                            (66)

       Female Rat No. - M2HF  (Path. No. 95672)
           Uterus - Chronic mild endometritis.

       Female Rat No. M30HF  (Path. No. 95343)
           Kidney - Focal calcification.
           Uterus - Chronic mild endometritis.

       Female Rat No. M30HF  (Path. No. 95675)
           Pancreas - Focal hyperplasia.

 The third phase of this review consisted of microscopic verification of
 all masses reported grossly at necropsy from all female animals not
 examined in phases 1 and 2 and included a total of 73 animals.  The
 inconsistencies are listed below:

       Female Rat No. D10Lf (Path No. 92521)
           Subcutaneous mass was diagnosed as an angiofibroma on Searle
           report.  The lesion is more consistent with an angiosarcoma.

       Female Rat No. K9MF (Path. No. 95707)
           Uterus - Polyp. 

       Female Rat No. M1LF (Path. No. 95844)
           Tissue mass seen grossly was reported as missing and not
           available for microscopic examination.  The tissue was
           present and was a mammary fibroadenoma

 In summary, Dr. Frith reviewed:

      1)   All 36 high dose females (all slides) including 3 that had
           been excluded from the study due to autolysis.

      2)   36 (one-half) of the control females (all slides) including
           1 animal that had been excluded from the study due to auto-
           lysis.

      3)   Remaining 73 female animals with grossly observed masses.
           (sufficient slides were reviewed to substantiate the masses)

      4)   5 additional animals selected by the investigators (A1HM,
           A9HM, A29HM, C2CM, C24HM).

                            (67)

 The slides reviewed in the first two categories above constituted 20% of
 the total animals on the study.  Dr. Frith reviewed these slides blindly
 and then compared his findings with the Searle microscopic reports.
 According to Dr. Frith, his findings were in agreement with those of
 SEarle, for the most part.  In his opinion, some of the lesions that he
 reported as inconsistencies were small, and might be considered
 insignificant by some pathologists.  Dr. Frith did feel, however, that the
 ovarian neoplasms (animals H10CF, H19CF, and H7HP, and chronic cystitis
 and diffuse hyperplasia (animal D29CF) should have been reported.

 Dr. Frith also considered two other discrepancies to be significant.  They
 were: 

       1)  The reporting of a mass (by Searle) as missing which was
           actually present (MlLF).

       2)  The finding of a polyp of the uterus which was not diagnosed
           by Searle (K9MF)

 The second of the above two discrepancies assumes even more significance
 in view of the following:

 The Histopathologic Summary table (table 11) in Volume I of the submission
 to FDA lists the following incidence of Uterine Polyps on page 87:

                     Incidence of Uterine Polyps

       Controls         Low             Medium           High
       1 of 69          1 of 34         4 of 34          6 of 33
         (1%)             (3%)           (12%)            (18%)

 The finding of one additional uterine polyp by Dr. Frith (in animal K9MF)
 increases the incidence in the mid dose to 5 of 34 (15%).

 On page 82 of Volume I of the submission to FDA, is the statement: "other
 sporadic findings is included endometrial hyperplasia, polyp, cyst,
 congestion and squamous metaplasia."  The term "sporadic findings" was
 used to characterize the incidence of uterine polyps, in spite of the fact
 that Searle had done a statistical analysis of these findings.

                            (68)




 The errors are tabulated below:

                                     Wt. Shown In          Wt. Recorded on
     Animal No.       Organ          Submission      Original Pathology Sheet

     A12CM            Kidneys           3.75 G             3.45 G
     L28LM            Ven. Prostrate    747 mg.            474.7 mg.
     C0lMM            Kidneys           9.40 G             9.219 G.
     C02HM            Kidneys           1.46 G             4.259 G
     E14HM            Kidneys           11.74 G            4.746 G
    J12HM            Pituitary         3.0 mg.            3.3 mg.
     J30HM            Ven. Prostrate    444 mg.            444.8 mg.
     F17CF            Ovaries           36.7 mg.           233.5 & 36.7 mg.
     H30CF            Liver             9.4 G              9.493 G
     B20HF            Uterus            1115 mg.           1155 mg.
     K11HF            Adrenals          799.1 mg.          797.1 mg.

                                (42)