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Sunday, August 8, 2010

Aspartame Causes Wt. Gain - Scientific Study

International Journal of Obesity (2004) 28, 933–935. doi:10.1038/sj.ijo.0802660 Published online 27 April 2004

A Pavlovian approach to the problem of obesity

T L Davidson1 and S E Swithers1

1Department of Psychological Sciences, Ingestive Behavior Research Center, Purdue University, West Lafayette, IN, USA

Correspondence: Dr TL Davidson, Department of Psychological Sciences, Purdue University, 703 Third Street, West Lafayette, IN 47906, USA. E-mail:

Received 6 September 2003; Revised 30 November 2003; Accepted 8 December 2003; Published online 27 April 2004.

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During the past 15–20 y, the incidence of overweight and obesity in the United States has grown rapidly. The processes that underlie this alarming trend remain largely unspecified. We hypothesize that degradation of the ability to use certain orosensory cues to predict the caloric consequences of intake may contribute to overeating and excessive weight gain. The results of two preliminary studies with rats are consistent with this hypothesis. In one study, the ability of rat pups to regulate their caloric intake after consuming a novel high-calorie, sweet food was disrupted if they had received prior training with sweet tastes that failed to predict the caloric consequences of eating. Another study found that altering the normal predictive relationship between food viscosity and calories led to increased body weight in adult rats. Dietary factors that degrade the relationship between sweet tastes, food viscosity and calories may contribute to overeating and weight gain.


Pavlovian, learning, sweet, viscosity, rat