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Wednesday, September 1, 2010

Skin Eruptions from Aspartame Ingestion - Dermatologist

  • Brief Reports

Aspartame-lnduced Urticaria

+Author Affiliations
  1. Washington University School of Medicine; 
    St. Louis, Missouri


    Aspartame (NutraSweet; G.D. Searle & Co., Skokie, Illinois), the dipeptide composed of aspartic acid and the methyl ester of phenylalanine, is a low-calorie artificial sweetener 180 times sweeter than sucrose (1, 2). Although questions have been raised about its safety (3-5), the Food and Drug Administration (FDA) approved aspartame for use in carbonated beverages in 1983, and currently it is used extensively in diet soft drinks, chewing gums, cereals, desserts, and sugar substitutes. One case of granulomatous panniculitis resulting from aspartame has been documented (6). This report describes a case of aspartame-induced urticaria confirmed by doubleblind challenge.
    A 23-year-old white
    This 100-word excerpt has been provided in the absence of an abstract.


    The case of a second patient, a 42-year-old white woman with a 4-month history of intermittent angioedema and urticaria, was also studied. This patient noted that several of her episodes developed within 1 hour of ingestion of aspartame-containing drinks. In a doubleblind, placebo-controlled challenge the patient developed urticaria on the forearms and neck within 90 minutes of challenge with 75 mg of aspartame.


    ACKNOWLEDGMENTS: The author thanks W. Gerald Klingler, M.D., and Rand Dankner, M.D. for referal of the patient; Jane Gold, R.N., and Mary Conboy for assisting with patient monitoring and P-K testing; and Casey Croy and Dr. Philip Korenblat for reviewing the manuscript.

    Article and Author Information

    • Data were provided by Dr. David G. Hattan from adverse drug reaction reports as of 22 April 1985 made to the Food and Drug Administration Center for Food Safety and Applied Nutrition.
    • Grant support: by grant 1P50 AI 15322-06 from the National Institutes of Health.
    • ▸Requests for reprints should be addressed to Anthony Kulczycki, Jr., M.D.; Division of Allergy and Immunology, Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue; St. Louis, MO 63110.

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